What Does THCV Do to Your Body and Mind?

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THC-V Isolate_ BT

THCV (tetrahydrocannabivarin) is a unique cannabinoid that interacts with the body and mind a bit differently than other cannabinoids like CBD and THC. This compound, found in cannabis, offers several potential health benefits that range from medical relief to recreational fun.

While THCV has a similar molecular structure to THC, it produces different, more pronounced effects. For example, where THC enhances appetite, THCV does not; the two compounds have different energy regulation, glucose metabolism, and glycemic control properties.

THC also has five side-chain carbon atoms while THCV has three. Both THCV and THC have similar structural features such as a hydrophobic alkyl chain and a dibenzopyran ring, but they interact with the endocannabinoid system (ECS) differently. Both THC and THCV interact with the ECS to regulate lipids, maintain homeostasis, and glucose metabolism. Their chemical structures lead to different results in how the human body utilizes and metabolizes them, which yields different results in people’s bodies and minds.

Curious about the benefits of THCV? Read on to learn more. 

May Help Suppress Appetite

THCV may act as an appetite suppressant because it blocks the CB1 receptor, which stimulates appetite.[1] The theory is that blocking the receptor will have the opposite effect, making it great for people looking to avoid the dreaded munchies. As for an actual change in weight, there seems to be no significant impact. 

This is unlike THC, which is known for inducing appetite. While THCV exhibits antagonistic activities at the cannabinoid receptor, THC acts as an agonist at the cannabinoid receptor to promote lipid and glucose intake.[2]

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[1] Riedel, G., Fadda, P., McKillop-Smith, S., Pertwee, R. G., Platt, B., & Robinson, L. (2009). Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice. British Journal of Pharmacology, 156(7), 1154–1166. https://doi.org/10.1111/j.1476-5381.2008.00107.x

[2] Institute of Medicine (US); Joy JE, Watson SJ Jr., Benson JA Jr., editors. Marijuana and Medicine: Assessing the Science Base. Washington (DC): National Academies Press (US); 1999. 4, The Medical Value of Marijuana and Related Substances. Available from: https://www.ncbi.nlm.nih.gov/books/NBK230711/

 

Could Help Manage Health Levels of Inflammation

THCV has been proven to decrease oxidative stress[1] and offer anti-inflammatory benefits[2]. This makes it useful for those looking to manage chronic issues related to inflammatory response.

May Aid in Anxiety and Mood Management

THCV shows promising results and when tested in a pilot study involving ten male cannabis users, THCV appeared to reduce the psychotic and paranoia effects and improved their short-term memory[3]. This is unlike THC, which could present challenges to those with anxiety. 

THCV may also help with tremors because it supports muscular control. Although additional research is needed, some say that the neuroprotective effects of THCV could make it suitable for a wide range of individuals including those exhibiting signs of a degenerative cognitive mental state.

 

References:

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[1] Valérie Wolff, Anna-Isabel Schlagowski, Olivier Rouyer, Anne-Laure Charles, François Singh, Cyril Auger, Valérie Schini-Kerth, Christian Marescaux, Jean-Sébastien Raul, Joffrey Zoll, Bernard Geny, "Tetrahydrocannabinol Induces Brain Mitochondrial Respiratory Chain Dysfunction and Increases Oxidative Stress: A Potential Mechanism Involved in Cannabis-Related Stroke", BioMed Research International, vol. 2015, Article ID 323706, 7 pages, 2015. https://doi.org/10.1155/2015/323706

[2] Anil, S.M., Shalev, N., Vinayaka, A.C. et al. Cannabis compounds exhibit anti-inflammatory activity in vitro in COVID-19-related inflammation in lung epithelial cells and pro-inflammatory activity in macrophages. Sci Rep 11, 1462 (2021). https://doi.org/10.1038/s41598-021-81049-2

[3] Englund, A., Atakan, Z., Kralj, A., Tunstall, N., Murray, R., & Morrison, P. (2015). The effect of five day dosing with THCV on THC-induced cognitive, psychological and physiological effects in healthy male human volunteers: A placebo-controlled, double-blind, crossover pilot trial. Journal of Psychopharmacology, 30(2), 140–151. https://doi.org/10.1177/0269881115615104

 

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