Black Tie hemp isn’t just beloved by our customers. Despite being a relatively new establishment, Black Tie has already won numerous awards for our CBD and hemp products. That’s why we wanted to show you highlights of our newest and best strains.

Here are our latest strains for 2022;

1. GRANDADDY PURPLE (INDOOR) CBD HEMP FLOWER

Grandaddy purple is a CBD-rich hemp flower, best to enjoy CBD at its safest source. This hemp strain specifically contains over 23.80% cannabinoids, and is extremely rich in terpenes like Myrcene.

Myrcene

On average, myrcene represents over 20% of the terpene profile in modern commercial strains, although individual samples vary widely in their terpene content. Herbal medicines containing myrcene have a long history of being used as a sleep aid in folk medicine.

Primary Terpenes: Ɓ-Farnesene, Beta-Myrcene, Linalool, Guaiol, Ɓ-Limonene (2.42%)

Primary Aromas:  Grapes, Berries, Candy
Smell Profile: This flower boasts a pungent "purple" scent - if you're familiar with the aroma of classic purple cannabis strains. The smell is a rich floral aroma with strong nodes of berries and candy. Pinch the buds to release a pungent Kush scent from within.
Taste Profile: Dry hit the blunt to reveal a bold, sweet grape flavor. The flavor is defined by tones of berries and cand. A mouth-watering flavor that is thick on the palate but smooth on the throat.
Preferred Time of Use: Afternoon / Evening
Phenotype: Indica-Dominant Hybrid
Density: Medium-High
Total CBD – 16.27%
THCa - .8%
THC (Delta9) - 0.07%
Total Cannabinoids Analyzed – 19.92%

2. ORANGE COOKIES (INDOOR) CBD Hemp Flower

ORANGE COOKIES -This indoor hybrid strain is aH-mazing. From the looks, to the taste, the experience, and the effects. The Orange Cookies are light green buds with bright orange hairs that glisten with trichomes, and is high in. This strain is a sativa-dominant hybrid marijuana strain made by crossing Orange Juice with the renowned Girl Scout Cookies.

The dominant terpene of Orange Cookies is Terpinolene.

As an essential oil, terpinolene may have antibacterial and antifungal qualities, according to a 2005 study. Terpinolene carries an array of smells you might find in cannabis: It’s piney, floral, herbaceous, and even a little citrusy.

Density: Medium - High
Primary Terpenes: Beta-Caryophyllene, A-Bisabolol, Guaiol
Primary Aromas: The buds present a sweet mandarin orange scent with kushy undertones.
Taste Profile: Take a dry hit on the joint/blunt to reveal a sweet mandarin orange flavor. The smoke is pleasant and tingling sensation in the mouth as well as a sweet orange aftertaste on the lips. A kushy backend lingers on the palate.
Preferred Time of Use: Daytime - Anytime
Phenotype: Hybrid
Total CBD - 14.5%
THC (Delta 9) - None Detected
Total Cannabinoids Analyzed - 15.78%

3. Delta8 Infused Sour Diesel CBD Hemp Flower

Sour Diesel, often called Sour D, is a sativa-dominant cross between Chemdog 91 and Super Skunk. Sour Diesel CBD has a 70:30 sativa-to-indica ratio. The chunky, forest green buds of the Sour D have a shine to them as this strain is heavily coated with Delta8.  Some reportedly experience mental stimulation in the form of creativity from this sativa-dominant delta8 infused hemp hybrid, producing medium to large-sized highly dense buds. This strain is dominant in the caryophyllene terpene.

Caryophyllene

The terpene caryophyllene is present in many herbs and spices, including black pepper, basil, and oregano, and cannabis strains with high levels of it deliver a spicy, funky warmth to the nose, similar to cinnamon and cloves. What makes caryophyllene an intriguing terpene is its relationship with our endocannabinoid system, particularly, its ability to bind to CB2 receptors. Because of this, it comes with a host of potential medical benefits.

Density: Medium-High

Primary Aromas: Pine, Stinky Cheese, Gasoline,

Smell Profile: The smell of the delta-8 coating is immediately detected upon opening the container. Pinch the buds to find the true smell of the buds within which begins with a hint of pine followed by a strong whiff of stinky cheese and finishes with nodes of truck stop Gasoline. It's funky in a real good way.

Taste Profile: This one is Gas. The taste is Diesel Fuel with a mild earthy undertone. The throat grab is medium to harsh as the delta8 coating makes for a heavy finish. May want to hit this one slowly.

Time of Day usage: Daytime / Afternoon

Phenotype: Sativa-Dominant Hybrid

Total Cannabinoids Analyzed – 42.5%

Total CBD – 13.74%

THC Δ8 - 27.54%

‍

Delta 9 gummies are the potent, slow-acting, long-lasting edibles you’ve been looking for. Designed to give you the boost you need, these gummies are known for their energetic and uplifting effects. Black Tie CBD’s Delta 9 gummie contain Sativa terpenes, Terpinolene, and alpha-pinene, and are fully compliant with the Farm Bill because they only contain 10 mg of THC per 5-gram piece

Our high-potency Delta 9 gummies are fully lab tested for potency and purity and are all-natural, vegan, gluten-free, and made without corn syrup.

People take Delta 9 gummies for a variety of reasons, some of which include helping alleviate symptoms associated with pain, anxiety, stress, and depression. If you’ve never taken Delta-9 gummies before, there are some things you should know about the product before buying Delta 9 gummies online.  

Delta 9 Gummies are Psychoactive

Delta 9 THC is known as one of the psychoactive cannabinoids in hemp and is responsible for the psychedelic effects that cannabis delivers. While these gummies may taste similar to other non-psychoactive CBD edibles, it’s important to keep in mind that they have psychoactive effects. Depending on the individual’s body weight and what they ate, it may take up to 45 minutes for Delta 9 gummies to fully kick in.  

Many people report feeling calm, relaxed, having better sleep, and having better appetites during the two-hour window in which Delta 9 gummies are at their strongest. In some cases, individuals reported a boost in creativity as well as more sensory and visceral experiences. We suggest starting with ½ a gummy and waiting 90 minutes before proceeding. Do not exceed 2 gummies in one sitting.

Delta 9 Gummies Do Not Require Prescription

Unlike medicinal cannabis, Delta 9 gummies do not require a doctor’s prescription, which makes  buying Delta 9 gummies online from Black Tie CBD easy. These edibles are not considered a controlled substance according to the 2018 Farm Bill, under which the Farming Act legalized hemp products with dry weight volume with less than 0.3% of the delta-9 THC.

Deltas 9 THC gummies that comply with this limitation law (including those sold by Black Tie CBD) and are derived from hemp, which means they can be sold online in the same way that many CBD products can without a medical prescription. Delta 9 THC gummies are not intended for medicinal use. Black Tie CBD does not claim that our products will cure or treat any health conditions.

Delta 9 Gummies are Different from Smoking Cannabis

Consuming the same substance but in different ways may yield different effects. Although the THC in Delta 9 gummies might be similar to the amount one might get through cannabis, the intensity and duration of the effects will likely vary. Ingesting Delta 9 gummies often takes up to 45 minutes before users see a difference; it also usually results in a deeper and stronger psychoactive, relaxing sensation that can last up to six hours.

Smoking cannabis, by contrast, tends to have effects immediately, but they will be less intense and last for a shorter period of up to four hours. The main determining factor for who should take Delta 9 gummies vs smoking cannabis typically depends on preference and how experienced of a cannabis consumer you are.  

They Should be Taken in Moderation

Users should always bear in mind that Delta 9 is psychoactive and should be taken in moderation. Common side effects from taking Delta 9 gummies (whether you purchase them online or in-store) are dizziness, paranoia, anxiety, tension, and stress.  

Shop Award-Winning & Premium CBD Products

Established in 2018, Black Tie CBD was created to provide customers with high-quality CBD products. We have five properties spanning 200 acres on which we grow the award-winning hemp that we use to produce most of our store's products.

Black Tie CBD is committed to quality and variety. We believe in providing our customers with full access to our curated selection of hemp products so they can enjoy all of their benefits.

For more information about our CBD products, please do not hesitate to contact us at 1-888-702-2285 today!

‍

The cannabis plant is home to over 200 cannabinoids and terpenes that have potential health benefits. Following the wild success of delta 8 THC as a legal alternative to the more controlled availability of delta 9 THC, the cannabis industry has sought other less-known cannabinoids to compete in the diverse cannabis marketplace. One of the newest, semi-synthetic cannabinoids called hexahydrocannabinol, usually shortened to HHC.

Hexahydrocannabinol (HHC) is a cannabinoid that was first discovered in the mid-1940s. In 1944, the American chemist Roger Adams created HHC when he added hydrogen molecules to Delta-9 THC. This process is known as "hydrogenation." HHC is found in limited quantities in the hemp plant. Although HHC is a naturally occurring compound, it is hard to obtain sufficient amounts to make products. But by certain production processes, companies can convert CBD into HHC to make a wide variety of products.

While HHC has been around for years, it has not been often discussed by cannabis users until recently.. HHC is a minor cannabinoid; it occurs naturally in cannabis, but in amounts too small to make extraction cost-effective - this means that for companies to sell this cannabinoid, they’re going to need to make it in a lab. HHC does, however, have one major legal advantage over delta 8 and delta 10: it isn’t THC.

So how is HHC made?

As mentioned above, Roger Adams is the first person to discover HHC using the process known as ‘hydrogenation’. There are a couple of different methodologies to hydrogenate delta-8 into HHC, but Hydrogenation is simply treating a compound with hydrogen, which causes a chemical reaction between hydrogen and another compound or element, usually in the presence of a catalyst such as nickel, palladium, or platinum. This is done in order to reduce or saturate organic compounds.

Adams originally applied this technique to THC derived from marijuana plants, but since the 2018 Farm Bill came into effect, legalizing cannabis crops with less than 0.3% delta-9 THC, more manufacturers are applying the hydrogenation of cannabinoids to CBD to produce HHC.

When it comes to HHC specifically, Hydrogenation modifies the structure of delta 9 THC by replacing a double bond with two hydrogen atoms, which changes its molecular weight and makes it more stable. According to chemist Mark Scialdone;

“A major benefit to hydrogenation is that it offers stability at the molecular level, assisting with both shelf life, and resistance to heat.”

It should be said, though, that the acronym “HHC'' is also used in scientific literature to refer to dangerous synthetic substances like 9-Nor-9β-hydroxyhexahydrocannabinol and 11-Nor-9β-hydroxyhexahydrocannabinol. All those Greek letters and super-long hyphenated chemical names are surefire signs that these forms of HHC are synthetic.

What Are The Effects Of HHC?

First, it’s important to note the different types of HHC that are available on the market. There are at least 10 types of HHC:

1. HHC — Hexahydrocannabinol (CAS# 6692-85-9)
2. 7-OH-HHC — 7-hydroxyhexahydrocannabinol (CAS 64663-39-4)
3. 8-OH-iso-HHC — 8-hydroxy-iso-hexahydrocannabinol (No CAS#)
4. 9α-OH-HHC — 9α-hydroxyhexahydrocannabinol (CAS# 52171-85-4)
5. 7-9α-OH-HHC — 7-oxo-9α-hydroxyhexahydrocannabinol (No CAS#)
6. 10α-OH-HHC — 10α-hydroxyhexahydrocannabinol (No CAS#)
7. 10α-ROH-HHC — 10aR-hydroxyhexahydrocannabinol (No CAS#)
8. HU211 — 1,1-Dimethylheptyl-11-hydroxytetrahydrocannabinol (CAS 112924-45-5)
9. HU243 — 11-Hydroxy-3-(1′,1′-dimethylheptyl)hexahydrocannabinol (CAS 140835-14-9)
10. HDHHC — 3-Dimethylheptyl-11-hydroxyhexahydrocannabinol (CAS 140835-18-3)

HHC has very similar effects to delta-9 THC—it's a psychotropic compound that produces feelings of euphoria, changes in perception, altered cognition, as well as other potential properties. When it takes on other forms, it becomes slightly more complicated. Many users report the effects of HHC are similar to that of delta 8 THC in terms of being more heavily weighted towards relaxation than stimulation. HHC is more potent than delta 8 but slightly less potent than delta 9 THC.

We've seen a sudden ride of THC isomers—variants of the notorious delta-9 THC molecule, as people look for a legal means to experience the intoxicating effects of marijuana. Popular THC cannabinoid analog isomers include delta-8 THC and delta-10 THC derived from hemp crops. Although HHC isn’t technically a THC, it does produce similar effects—if you use enough of it. When it’s produced in the lab, an HHC batch is a mix of active and inactive HHC molecules. The active HHC binds well with your body’s cannabinoid receptors; the others don’t.

A study published in 2010 found that HHC’s effects lasted a long time in rats. Overall, apart from the limited research outlined in this section, there is nothing else to link HHC with the benefits claimed by manufacturers. Certainly, there are no studies on humans that provide any insight.

Is HHC Legal?

Although HHC is not the same as THC, it is potentially illegal if deemed synthetic. The FDA’s Interim Final Rule (IFR) states that synthetic cannabinoids in hemp are illegal, while naturally-occurring ones are permitted. It is true that HHC occurs naturally in hemp and cannabis but only in tiny amounts. HHC manufacturers make it in a lab via a chemical process designed to create more of it.

With the rise of delta 8, hexahydrocannabinol was recognized as yet another form of “legal THC” capable of being sold to the masses. No matter how much marketing material you read, however, delta 8 and HHC will never be equitable. One is a synthetically derived cannabinoid while the other is a natural substance.

We wouldn’t be surprised if HHC starts getting attention from the DEA, as we suspect that considering the need to synthetically create it - HHC falls under the Federal Analogue Act, which automatically classifies analogs of Schedule 1 drugs as Schedule 1 drugs themselves. If the DEA agrees, HHC could have a very short market span.

Is HHC Safe?

As it stands, HHC is rarer and more difficult to derive than delta 8, the HHC market is smaller and less competitive, resulting in comparatively inferior products. Because hexahydrocannabinol (HHC) is still very new, there aren't very many studies available that investigate its potential effects and safety - which is enough to tell us that as it stands, it is not particularly safe.

With the limited research on HHC, we highly suggest that you stick to the better known cannabinoids with ample research surrounding it like CBDV which we have done extensive research into and offer safe, legal products containing this cannabinoid.

HHC seems to be following a very similar and dangerous route to THCO, another synthetic cannabinoid taking the industry by storm. We can only hope that the search for something stronger and different does not take priority over the search for something more beneficial and well-researched.

‍

With Covid-19 impacting us for the last two years, the world is rapidly searching for ways that we can effectively manage the virus, despite the variants that constantly pop up. Finally, it seems that research is progressing and it’s the cannabis industry at the forefront of the latest research advancements by researchers affiliated with Oregon State University. These researchers conducted a study that suggests that cannabis compounds prevent Infection by the Covid-19 Virus.

The COVID-19 pandemic includes at least 272 million cases worldwide, 5.3 million deaths, and over 600 000 new cases daily. While the rollout of vaccines is underway, the rapid spread of COVID-19 underscores the need for new treatments.

Background Information:

In January 2021, this study looked into the possibility that cannabis may offer some help for patients with COVID-19. The study looks at one of the primary biological events that occur in patients with severe acute respiratory distress cases from COVID-19, something called a “cytokine storm.”

C.Sativa, a type of cannabis, was found in a cytokine storm study to reduce multiple cytokines and pathways related to inflammation and fibrosis. Two of the cytokines that C.Sativa reduced were TNFa and IL-6, which are thought to be the main targets when trying to block a COVID-19 cytokine storm and acute respiratory distress syndrome.

In another study done in September of 2020 on mice, they found the following;

“Several reports demonstrated that cannabidiol (CBD), a phytocannabinoid produced by the cannabis plant, can block IL-6 in several models of inflammatory diseases.”

What do the studies say in 2022?

A report on the research, “Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants,” was published online on January 10th, 2022 by the Journal of Natural Products.

COVID-19 is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Researchers have found that the viral spike protein of SARS-CoV-2 to the human cell surface receptor angiotensin converting enzyme-2 (ACE2) is a critical step during the infection of human cells. The researchers looked into the following possibility:

“Therefore, cell entry inhibitors could be used to prevent SARS-CoV-2 infection as well as to shorten the course of COVID-19 infections by preventing virus particles from infecting human cells.”

Researchers discovered that cannabinoids increase the cell’s response to several key proteins produced by the coronavirus genome, which is an effect that had not been discovered prior to the study. Researchers also looked at how the proteins from the genome operated in human kidney cells and healthy control cells, both with and without cannabinoids.

Cannabis and its effectiveness against new variants:

The spike protein is the same part of the virus targeted by Covid-19 vaccines and antibody therapies. In addition to the spike protein, SARS-CoV-2 has three more structural proteins as well as 16 nonstructural proteins and several compounds van Breemen characterized as “accessory” proteins, all of which are potential targets for drugs developed to prevent Covid-19.

The two compounds commonly found in hemp - called cannabigerolic acid, or CBGA, and cannabidiolic acid, or CBDA - were identified during a chemical screening effort as having potential to combat coronavirus. In the study led by Richard van Breemen, a researcher with Oregon State’s Global Hemp Innovation Center, they found that cannabinoids bound to spike proteins found on the virus and blocked a step the pathogen uses to infect people, stating that;

“Cannabigerolic acid and cannabidiolic acid prevented infection of human epithelial cells”

This means that cell entry inhibitors, like the acids from hemp, could be used to prevent SARS-CoV-2 infection and also to shorten infections by preventing virus particles from infecting human cells. They bind to the spike proteins so those proteins can’t bind to the ACE2 enzyme, which is abundant on the outer membrane of endothelial cells in the lungs and other organs.

The study then goes on to state that the most important piece of evidence found was that CBGA and CBDA were equally as effective against the alpha and beta variants. The abstract ends off on a highly positive note, expressing that cannabinoids do in fact have the potential to prevent and likely treat infection by SARS-CoV-2.

What other benefits could cannabis pose for Covid-19?

‍

1. Anxiety
   The number of people reporting high levels of anxiety has sharply elevated during the coronavirus (COVID-19) pandemic. The factors most strongly associated with high anxiety during the pandemic include loneliness, marital status, sex, disability, whether someone feels safe at home or not and work being affected by the coronavirus (COVID-19) pandemic.
   
   There is understandable concern about the impact of the pandemic on people’s well-being. Fortunately, though, compounds within cannabis have shown impressive anxiety-reducing qualities, particularly CBD, which has been shown in studies to increase serotonin activity and lower cortisol levels.

Is Cannabis safe to consume for Covid-19 patients?

While most people consume cannabis by smoking it, it is not the only way to consume it. Companies like ourselves offer multiple variations of consumption like edibles, tinctures and more that have very low THC, yet still offer the same benefits.

After the last two years of uncertainty, illness and chaos due to the pandemic, it’s relieving to see that cannabis has shown a lot of potential in fighting against COVID-19 and could potentially offer new solutions to tackle the pandemic.

Where can you get CBDA and CBGA products from?

The team here at Black Tie CBD is relieved and grateful that we’re a part of an industry that is helping to better global health in such an impactful way. As a company, we've seen the value in CBDA products and we've just released our brand new CBDA isolate so you can keep safe too.

‍

With countries worldwide slowly legalizing cannabis, research is finally growing and we’re constantly finding out more about the 120+ cannabinoids in the marijuana plant, namely CBDV, otherwise known as Cannabidivarin. 

People are looking beyond conventional THC or CBD and seeking out new cannabinoids like this one, and in this article, we will explain why CBDV is worth looking into. The laws have limited public access and therapeutic research on non-psychoactive cannabinoids. Fortunately, we’re discovering more and more cannabinoids that are non-psychoactive and still have the healing properties of cannabis.

So, what is CBDV?

Cannabidivarin (CBDV) is a Varin cannabinoid first reported in a benzene extract from a Thai cannabis variety referred to as “Meao” in 1977, and identified for the first time in 1969 Vollner et al. CBDV is a homolog of CBD and is a non-psychoactive cannabinoid. As you can see below, The slight difference here is the propyl chain that CBDV carries. 

Like CBD, cannabidivarin has 7 double bond isomers and 30 stereoisomers. There is a side-chain shortened by two methylene bridges. The biggest difference between CBD and CBDV is their concentrations in the cannabis plant. You can find trace amounts of CBDV in high-quality full-spectrum and broad-spectrum extracts that help to produce the entourage effect.

Varin cannabinoids (technically called varinolic cannabinoids) are a subfamily of cannabinoids that feature three carbons on their alkyl side chains. The most well-known examples are THCV, CBDV, CBGV, and CBCV. There are also acid forms of THCVA, CBDVA, CBGVA, and CBCVA.

CBDV exists in very small quantities. Recently, several African landrace strains (which are genetically pure and unimpacted by experimentation) of Cannabis indica were found to have CBDV and the related THCV in concentrations closer to 4%. There are also plant breeders creating high CBDV and THCV strains of hemp and marijuana — but the current record still sits below 7% CBDV. 

What are the medicinal effects?

Epilepsy

Due to the rise in popularity of CBDV, researchers are trying to discover its medical benefits. In 2014, GW Pharmaceuticals finished a Phase 1 clinical trial of its CBDV test product (known as GWP42006). The clinical trial explored the use of CBDV as an anti-epileptic drug. The company continues to research CBDV heavily. You won’t feel a psychoactive ‘high’ from CBDV. Instead, you can expect it similar effects to CBD. The lack of a ‘high’ means we can use CBDV similarly, which is still being researched.

GW were set to enter Phase III trials in late 2019 but had to terminate the study because of the pandemic. They’re currently recruiting for a new trial, and the CEO Justin Gover made the following statement;

“CBDV represents an additional product pipeline opportunity as a next-generation epilepsy therapy.”

This study follows the completion of a Phase 1 trial in 66 healthy subjects in 2014. In this trial, CBDV was well tolerated even at the highest tested dose and no significant side effects were observed. Most importantly, following this trial, There were no serious or severe adverse events, nor any withdrawals due to adverse events.

Rett Syndrome

As you may know, Rett syndrome (RTT) is a rare neurodevelopmental disorder, characterized by severe behavioral and physiological symptoms with no cure available to date. A study was done on mice with CBDV being administered for 14 days. The study restored compromised general health status of the mice, the sociability, and the brain weight in RTT. While more studies are required, this shows great promise for the medical use of CBDV.

Autism

Some of the most interesting recent research into CBDV has been around the subject of autism. This condition, which affects more children and adults every year, is still being researched to find effective medications. The use of CBDV for autism has rapidly gained popularity over the last two years.

The study suggests that CBDV targets subcortical excitatory glutamate systems both in autistic and neurotypical adults. This study compared the effects of CBDV in neurodiverse patients and neurotypical patients. They noted a higher degree of difference in ASD patients with elevated glutamate. Very little benefit was reported on those with normal glutamate levels.

Some studies have even shown that people diagnosed with autism spectrum disorder (ASD) have below-average anandamide levels in the brain, one of the body’s endocannabinoids. 

Pain

In this study, patients underwent two successive treatment phases (4 weeks each) and were treated with CBDV. While the study wasn’t necessarily conclusive, it did explore the potential utility of CBDV for neuropathic pain. 

While CBDV research is increasing, so far there are no guarantees that cures or applications have been or will be found. The existing CBDV studies and research papers indicate grounds for medical optimism that previously may not have existed. With the growing interest in the industry, there’s endless potential. Fortunately, there should not be severe restrictions on CBDV, considering its lack of psycho-activity. 

CBDV and the endocannabinoid system:

CBDV interacts with the endocannabinoid system (ECS) the same way as CBD. However, it’s thought to have about 25% of CBD potency. CBDV does not stimulate the ECS as CBD and THC do; it has a modulating action instead. According to the British Pharmacological Society;

“CBDV and all the acids inhibited DAGLα.”

DAGLα is an enzyme responsible for the synthesis of the endocannabinoid 2-AG.

Is CBDV Legal? 

CBDV is legal in the United States, as long as it is produced from Hemp rather than marijuana. This is because CBDV derived from marijuana is illegal on a federal level and is considered a schedule 1 drug by the Drug Enforcement Agency (DEA). Some states have legalized marijuana for medicinal or recreational use. The states that have legalized marijuana have also legalized its derivatives, including CBDV. 

CBDV derived from hemp containing no more than 0.3 percent THC is considered legal on a federal level due to the 2018 Farm Bill. This Bill gave states the power to further regulate hemp products, which some states have by restricting any traces of THC. Although hemp-derived CBDV is difficult to find, it’s legal in all states as long as it abides by the state THC regulations. 

What is the difference between CBDV and CBD?

As previously mentioned, the molecular structures between CBD and CBDV are different, which impacts their chemical responses. Furthermore, CBDV can be used to develop THCV (tetrahydrocannabivarin) when it’s exposed to an acidic environment. CBD doesn’t have this same ability to transform into THC. When dealing with CBDV vs CBD, both cannabinoids share huge similarities that could be a massive hit in the medical industry because of the therapeutic effects offered. Above all, CBD and CBDV both interact with the endocannabinoid system, but CBDV binds with the cannabinoid receptors and CBD simply interacts or blocks the receptors.

Based on all the information provided, it’s clear why Cannabidivarin might be the next significant cannabinoid the world will witness, and we can only hope that research increases to increase the use of CBDV globally.

With countries worldwide slowly legalizing cannabis, research is finally growing and we’re constantly finding out more about the 120+ cannabinoids in the marijuana plant, namely CBDV, otherwise known as Cannabidivarin. 

People are looking beyond conventional THC or CBD and seeking out new cannabinoids like this one, and in this article, we will explain why CBDV is worth looking into. The laws have limited public access and therapeutic research on non-psychoactive cannabinoids. Fortunately, we’re discovering more and more cannabinoids that are non-psychoactive and still have the healing properties of cannabis.

So, what is CBDV?

Cannabidivarin (CBDV) is a Varin cannabinoid first reported in a benzene extract from a Thai cannabis variety referred to as “Meao” in 1977, and identified for the first time in 1969 Vollner et al. CBDV is a homolog of CBD and is a non-psychoactive cannabinoid. As you can see below, The slight difference here is the propyl chain that CBDV carries. 

Like CBD, cannabidivarin has 7 double bond isomers and 30 stereoisomers. There is a side-chain shortened by two methylene bridges. The biggest difference between CBD and CBDV is their concentrations in the cannabis plant. You can find trace amounts of CBDV in high-quality full-spectrum and broad-spectrum extracts that help to produce the entourage effect.

Varin cannabinoids (technically called varinolic cannabinoids) are a subfamily of cannabinoids that feature three carbons on their alkyl side chains. The most well-known examples are THCV, CBDV, CBGV, and CBCV. There are also acid forms of THCVA, CBDVA, CBGVA, and CBCVA.

CBDV exists in very small quantities. Recently, several African landrace strains (which are genetically pure and unimpacted by experimentation) of Cannabis indica were found to have CBDV and the related THCV in concentrations closer to 4%. There are also plant breeders creating high CBDV and THCV strains of hemp and marijuana — but the current record still sits below 7% CBDV. 

What are the medicinal effects?

Epilepsy

Due to the rise in popularity of CBDV, researchers are trying to discover its medical benefits. In 2014, GW Pharmaceuticals finished a Phase 1 clinical trial of its CBDV test product (known as GWP42006). The clinical trial explored the use of CBDV as an anti-epileptic drug. The company continues to research CBDV heavily. You won’t feel a psychoactive ‘high’ from CBDV. Instead, you can expect it similar effects to CBD. The lack of a ‘high’ means we can use CBDV similarly, which is still being researched.

GW were set to enter Phase III trials in late 2019 but had to terminate the study because of the pandemic. They’re currently recruiting for a new trial, and the CEO Justin Gover made the following statement;

“CBDV represents an additional product pipeline opportunity as a next-generation epilepsy therapy.”

This study follows the completion of a Phase 1 trial in 66 healthy subjects in 2014. In this trial, CBDV was well tolerated even at the highest tested dose and no significant side effects were observed. Most importantly, following this trial, There were no serious or severe adverse events, nor any withdrawals due to adverse events.

Rett Syndrome

As you may know, Rett syndrome (RTT) is a rare neurodevelopmental disorder, characterized by severe behavioral and physiological symptoms with no cure available to date. A study was done on mice with CBDV being administered for 14 days. The study restored compromised general health status of the mice, the sociability, and the brain weight in RTT. While more studies are required, this shows great promise for the medical use of CBDV.

Autism

Some of the most interesting recent research into CBDV has been around the subject of autism. This condition, which affects more children and adults every year, is still being researched to find effective medications. The use of CBDV for autism has rapidly gained popularity over the last two years.

The study suggests that CBDV targets subcortical excitatory glutamate systems both in autistic and neurotypical adults. This study compared the effects of CBDV in neurodiverse patients and neurotypical patients. They noted a higher degree of difference in ASD patients with elevated glutamate. Very little benefit was reported on those with normal glutamate levels.

Some studies have even shown that people diagnosed with autism spectrum disorder (ASD) have below-average anandamide levels in the brain, one of the body’s endocannabinoids. 

Pain

In this study, patients underwent two successive treatment phases (4 weeks each) and were treated with CBDV. While the study wasn’t necessarily conclusive, it did explore the potential utility of CBDV for neuropathic pain. 

While CBDV research is increasing, so far there are no guarantees that cures or applications have been or will be found. The existing CBDV studies and research papers indicate grounds for medical optimism that previously may not have existed. With the growing interest in the industry, there’s endless potential. Fortunately, there should not be severe restrictions on CBDV, considering its lack of psycho-activity. 

CBDV and the endocannabinoid system:

CBDV interacts with the endocannabinoid system (ECS) the same way as CBD. However, it’s thought to have about 25% of CBD potency. CBDV does not stimulate the ECS as CBD and THC do; it has a modulating action instead. According to the British Pharmacological Society;

“CBDV and all the acids inhibited DAGLα.”

DAGLα is an enzyme responsible for the synthesis of the endocannabinoid 2-AG.

Is CBDV Legal? 

CBDV is legal in the United States, as long as it is produced from Hemp rather than marijuana. This is because CBDV derived from marijuana is illegal on a federal level and is considered a schedule 1 drug by the Drug Enforcement Agency (DEA). Some states have legalized marijuana for medicinal or recreational use. The states that have legalized marijuana have also legalized its derivatives, including CBDV. 

CBDV derived from hemp containing no more than 0.3 percent THC is considered legal on a federal level due to the 2018 Farm Bill. This Bill gave states the power to further regulate hemp products, which some states have by restricting any traces of THC. Although hemp-derived CBDV is difficult to find, it’s legal in all states as long as it abides by the state THC regulations. 

What is the difference between CBDV and CBD?

As previously mentioned, the molecular structures between CBD and CBDV are different, which impacts their chemical responses. Furthermore, CBDV can be used to develop THCV (tetrahydrocannabivarin) when it’s exposed to an acidic environment. CBD doesn’t have this same ability to transform into THC. When dealing with CBDV vs CBD, both cannabinoids share huge similarities that could be a massive hit in the medical industry because of the therapeutic effects offered. Above all, CBD and CBDV both interact with the endocannabinoid system, but CBDV binds with the cannabinoid receptors and CBD simply interacts or blocks the receptors.

Based on all the information provided, it’s clear why Cannabidivarin might be the next significant cannabinoid the world will witness, and we can only hope that research increases to increase the use of CBDV globally.